21st North American ISSX Meeting Exhibitors
908 Devices ZipChip™ is radically improving process efficiencies for automated sample analysis of small and large molecules across the biopharma industry. This innovative CE platform provides high-quality separations as a front-end for mass spectrometry (MS). Using integrated microfluidic technology, ZipChip prepares, separates and electrosprays biological samples directly into MS instruments.
Absorption Systems supports pharmaceutical and medical device companies in identifying and overcoming ADMET barriers in development of drugs and medical devices. The company’s mission is to continually develop innovative research tools that can be used to accurately predict human outcomes or to explain unanticipated human outcomes when they occur. Visit www.absorption.com to view our comprehensive contract
services and applied research programs.
Agilent is a leader in life science research tools, providing analytical instruments, software, consumables and services for research laboratories worldwide. Agilent products including Seahorse, iLab, Dako, SureSelect, and mass spec are used in phenotyping, metabolomics, cell metabolism, and mitochondrial toxicity assays; as well as immunotherapy, cancer, and metabolic disease research.
Alliance Pharma is a contract research organization (CRO) established in 2008 that specializes in advanced bioanalytical research services for both small and large molecule drugs, as well as drug metabolism studies for pharmaceutical and biotechnology companies. Our facility is located at 17 Lee Boulevard in Malvern, PA.
ALTURAS ANALYTICS, INC.
Alturas Analytics delivers bioanalytical results on time with the highest level of integrity. Our business is built on developing long term collaborations with our clients by providing advanced MS/MS solutions through a focused emphasis on teamwork, communication,
and exceptional science. We are the MS/MS experts.
Analiza, Inc. is a leading US-based provider of complete analytical services supporting drug discovery. We offer expertise from physicochemical and ADME property screening to fully customized HPLC and LC-MS based analytical studies. We deliver quality data with the fastest
turn-around time, smallest sample requirement, and lowest cost in the industry.
Biomere is a preclinical CRO located in Worcester, MA. Founded in 1996, our scientific expertise in metabolic and autoimmune disease has since expanded to a comprehensive profile of various therapeutic areas. With colonies of rodents to NHPs, we are the number one choice for CROs for all your discovery needs.
BioreclamationIVT is a worldwide provider of biological and in vitro products to pharmaceutical and biotechnology organizations. Our company specializes in animal, human and disease state human biological matrices for use in drug discovery along with LiverPool and cryoplateable hepatocyte, microsome and media products used in the preclinical industry.
CELL RESOURCE CORE, MASSACHUSETTS GENERAL HOSPITAL
The Cell Resource Core specializes in hepatocyte isolations, whole liver perfusion studies and cell culture products. Our core’s uniquely broad proprietary technologies and products is the result of over 30 years of medical, scientific and engineering collaborations at Massachusetts General Hospital.
CORNING LIFE SCIENCES
Corning is the industry leader in the development of tools and solutions for ADME/Tox testing. Corning offerings include hepatic cell-based models, tissue fractions, recombinant enzymes, Transwell® Permeable Supports, as well as Contract Services for drug metabolism/transport/
toxicity studies. In addition, Corning continues to be the industry’s most reliable source of beginning-to-end cell culture solutions with trusted brands, such as Falcon® products, Matrigel® matrix, and cell culture media.
Custom Synthesis of Radiolabeling with 14C and/or 3H
- Carbon-14 radiolabeled small molecules for pre-clinical study and clinical trials
- H-3 radiolabeled compounds
- Stable isotope labeling
- Non-labeled Synthesis of Metabolites, Impurities and Reference Standards
- Peptide, Protein, Antibody, Recommbinant protein (intact or modified)
- Nucleic acid
- Antibody Drug Conjugate
- PEG polymer
Cypex specialises in the production of high quality recombinant enzymes including human CYPs, AOX, ALDH, GSTs and SULTs, and a range of CYPs from other species. Also available are antibodies, purified CYPs, substrates and inhibitors. Contract services include CYP inhibition, protein expression and metabolite generation. All products and services are covered by Cypex’s ISO9001:2008 accredited QA system.
Cyprotex (www.cyprotex.com) was founded in 1999 and specialises in in vitro and in silico ADME-Tox. The company has sites in the UK and the US. In 2016, Cyprotex was acquired by Evotec AG, enabling the company to offer both integrated and standalone drug discovery services.
Envigo provides essential research services, models and products for biopharmaceutical, crop protection, and chemical companies as well as universities, governments, and other research organizations. Our business is founded on a dedication to customer service and the expertise and experience of our 3,800 people. Read more at envigo.com.
EUROFINS PHARMA DISCOVERY SERVICES
Eurofins Pharma Discovery Services has been supporting Drug Discovery research for >40 years. Through the combined expertise of Eurofins Discovery Services, Cerep, Panlabs & Villapharma we offer a broad portfolio of products and services including; in vitro pharmacology, cell-based phenotypic assays, chemistry services, ADME-Tox, in vivo drug safety & efficacy, custom proteins and assay development services.
GENOMEMBRANE CO., LTD.
GenoMembrane Co., Ltd specializes in the research and development of drug transporters. We provide transporterrelated products and research services. In order to contribute to pharmacokinetic study, we offer ABC transporter vesicle products and transiently expressed SLC transporter cells to help our clients to facilitate the discovery of their new drug.
Hera BioLabs is focused on providing services with precisely gene-edited models to produce high-confidence and translational data. Our diverse capabilities include custom model creation, HepG2-CYP cell panel, huMDCK cells for transporter assays, and our SRG rat model for xenografts and humanization of the liver and humanization of the immune system.
HuREL® develops and sells primary hepatic co-cultures in a variety of species and formats. HuREL’s robust co-cultures offer superior metabolic functionality helping researchers produce more relevant data. Focusing on commercial practicality and convenience, HuREL delivers its products ready to use, including all necessary media; saving valuable time and money.
Hypha Discovery make drug metabolites for clients using proven microbial and mammalian biotransformation expertise. The technology is successful for Phase I oxidised metabolites and Phase II conjugates such as glucuronides and sulfates. Scalability enables provision of mg to gram amounts of metabolites for MetID, DMPK/Tox. or use as analytical standards.
Localized in USA, Europe and Asia, ImaBiotech is a Contract Research Organization (CRO) company which supports pharmaceutical compagnies with innovative services from preclinical to clinical stages. ImaBiotech is specialized in a new technology called Mass Spectrometry Imaging which improves Target Engagement, Pharmacokinetics, pharmacodynamics and support of toxicology studies.
IN VITRO ADMET LABORATORIES INC. (IVAL)
Premiere provider of in vitro drug metabolism and toxicology products and contract research services. IVAL provides comprehensive in vitro ADMET contract research services including metabolic stability, metabolite profiling, P450 inhibition and induction, transporter inhibition, and in vitro toxicity. Products include cryopreserved primary hepatocytes and primary cryopreserved enterocytes.
InterVivo Solutions is a preclinical in vivo CRO providing research services using translational animal models for efficacy, pharmacokinetics, safety and toxicology, including studies with the PXB Humanized Liver Mouse ® and Horizon/SAGE ® Knockout Rats. InterVivo specializes in CNS drug discovery and is unique in its offering of translational models and multidomain services to improve the clinical success of NCEs.
LABLOGIC SYSTEMS, INC.
LabLogic Systems is a worldwide market leader in the supply of LIMS and chromatography data systems to pharmaceutical, academic, nuclear medicine and research laboratories. Our products include LIMS for ADME studies and PET production, radiochromatography detectors and software for HPLC and TLC, liquid scintillation and gamma counters.
Lhasa Limited creates expert predictive software for use by life scientists in a variety of workflows and regulatory submissions; for example, Meteor Nexus, with different methodologies for assessing metabolism, is well placed to assist in DMPK studies. Other products include Derek Nexus and Zeneth for toxicity and degradation prediction, respectively.
Lonza Bioscience Solutions provides instruments, research tools and software throughout the entire pharmaceutical value chain, from drug discovery, ADME/Tox to Quality Control. Our integrated portfolio of transfection instruments and primary cells, now including hepatocytes, allows seamless screening of CRISPR libraries for phenotypic screening as well as early ADME/Tox investigations.
MicroConstants is a GLP-compliant Contract Research Organization focused on performing bioanalysis, drug metabolism, and pharmacokinetic analysis in support of new therapeutic development programs. We specialize in method development, validation, and sample analysis for small
molecules and macromolecules using LC/MS/MS, HPLC/UV, and immunoassay techniques.
For ADME/Tox and DMPK scientists performing Tier1/Tier2 safety testing assays, MilliporeSigma provides more predictive in vitro model systems for intestine, liver, and kidney with primary, wild type, and engineered cell lines. These systems, listed in FDA and EMA preclinical guidance documents, address transporters and nuclear receptors related to cyp induction.
MIMETAS develops better predictive human tissue and disease models using organ-on-a-chip technology. Her coreproduct, the OrganoPlate®, allows perfused 3D cell culture, membrane free co-culture and culture of tubules and vessels. MIMETAS works for nearly all major pharmaceutical companies worldwide on a variety of models for compound screening and toxicity testing.
Nexcelom’s Cellometer and Celigo image cytometry products are esigned for cell analysis in life science and biomedical research. The Cellometer instruments cover basic cell counting, viability and cell-based assays with 20uL of sample. The Celigo is a high throughput micro-well image cytometer. Products are placed in thousands of laboratories globally.
Omni International’s homogenizers have been a laboratory staple for over 60 years. Omni sets the industry standard with a commitment to outstanding design, performance and a uniquely diversified solution-based product line. We offer a complete portfolio of homogenizers and reagents for sample preparation in pharmaceutical, life science, biotechnology, agricultural, microbiology and chemical research laboratories.
Optibrium creates elegant software solutions for small molecule design, optimisation and data analysis, including: StarDropTM, a comprehensive environment that guides the design and selection of high quality compounds; SentiraTM, a powerful and easy-to-use desktop tool for chemistry data visualisation; and Asteris, an iPadTM app for creative compound exploration and design.
Optivia Biotechnology is a leading contract research organization (CRO) that offers drug transporter research services, products, and customized solutions for DDI, DMPK, safety, and pharmacology. Our award-winning transporter assay services provide high-quality, comprehensive FDA/EMA/ PMDA-compliant transporter inhibition and substrate assays, serving over 300 biotechnology, pharmaceutical and academic organizations worldwide.
Peak Scientific produces market-leading nitrogen, hydrogen and zero air systems mainly for the fields of LC-MS (Liquid Chromatography-Mass Spectrometry) and GC (Gas Chromatography). What differentiates us is our world-class technical support and ongoing service care throughout the generator’s lifespan, wherever you may be in the world.
Pharmaron is a premier R&D service provider. Founded in 2003, Pharmaron has established diverse drug R&D service capabilities, ranging from synthetic, medicinal and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled
metabolism, chemical & pharmaceutical development to clinical development, including applications of 14C microtracer AMS technology. www.pharmaron.com.
PHOENIXBIO USA CORPORATION
PhoenixBio produces the PXB-Mouse®, the world’s most widely used humanized liver chimeric mouse model for drug discovery and development. With a liver consisting of up to 98% human hepatocytes, the in vivo PXB-Mouse® model optimizes pre-clinical drug development with accurate human translatability for DMPK/Tox, NASH/NAFLD, Oligonucleotide Therapeutics and HBV/HCV fields.
Protea Biosciences provides services and consumables for mass spectrometry imaging (MSI), proteomics, protein characterization, and small molecule analysis. Protea’s innovative mass spectrometry technology featured in our service laboratory include the LAESI DP-1000 Direct Ionization System for ambient pressure, matrix-free applications, MALDITOF tissue imaging workflows, and high resolution, accurate mass bioanalytical LC-MS capabilities. Our interdisciplinary team offers the expertise to support researchers’ projects and help accelerate drug discovery and characterization. Learn how Protea Biosciences can enhance the quality of your research and reduce your time to market.
Launched in 2015, Q2 Solutions is a global clinical trials laboratory services organization that helps biopharmaceutical, medical device and diagnostics customers improve human health through innovation that transforms science and data into actionable medical insights. Q2 Solutions offers complete bioanalytical and ADME solutions for testing across the product development spectrum.
QPS is a GLP/GCP-compliant CRO that supports discovery, preclinical, and clinical drug development. We provide quality services in Neuropharmacology, DMPK, Toxicology, Bioanalysis, Translational Medicine, and Clinical Development to pharmaceutical and biotech clients worldwide. Our regional laboratories, clinical facilities and offices are located in North America, Europe, India and Asia. For more information, visit https://www.qps.com.
QUALYST TRANSPORTER SOLUTIONS, LLC
Qualyst provides in vitro hepatic models to predict the effect of compounds on the human liver. Qualyst’s models integrate hepatic uptake, metabolism, regulation, and efflux and demonstrate superior in vitro-in vivo correlation compared to conventional systems. The model data informs drug R&D decisions and is used to address regulatory concerns.
Quotient Clinical is a world leading provider of human ADME studies to the pharmaceutical industry generating data to support global regulatory submissions. Our integrated GMP manufacturing and GCP clinical facility with dedicated capability for the conduct of conventional and tracer radiolabelled studies offers a unique solution for pharmaceutical companies needing to generate human metabolism and pharmacokinetic data to support drug development and registration.
SAI LIFE SCIENCES
Sai Life Sciences provides services to our pharma innovator partners, which accelerate the discovery, development and manufacture of complex small molecules. Our clients gain clear competitive advantages through shorter time to market and risk minimization using our integrated and high-quality scientific services. Through our comprehensive discovery groups, Sai provides high-value integrated services in pharmacology, DMPK, toxicology and formulation development to better support the increasing needs of our customers.
Sekisui XenoTech is a global Contract Research Organization with unparalleled experience and proven expertise from discovery through clinical support, providing cell and tissuebased products, screening, radiolabeling, API manufacturing, in vitro ADMET and pharmacology, in vivo ADMET and QWBA, metabolite ID and production, bioanalytical services and consulting. Learn more at www.xenotech.com.
SEVENTH WAVE LABORATORIES
Seventh Wave represents a unique alternative to traditional contract research. We integrate nonclinical disciplines in pharmacology, drug metabolism & pharmacokinetics, toxicology and pathology to provide robust nonclinical evaluations of drug efficacy, safety, systemic exposure and metabolism. With a consultative, flexible, integrated and multi-disciplinary approach, we offer the advice, analysis and answers necessary to bring your drug to market.
Simulations Plus is the premier developer of modeling & simulation solutions supporting drug discovery and development. With subsidiary companies Cognigen & DILIsym, we provide easy-to-use software (including GastroPlus™, ADMET Predictor™, KIWI™, and DILIsym®) and
PBPK modeling, pharmacometrics, and systems toxicology/ pharmacology consulting to assist with safety risk assessment and preclinical/clinical development.
SOLVO BIOTECHNOLOGY US
Drug Transporter Services and Products from the Expert! SOLVO Biotechnology is the leading provider of transporter assays Worldwide, since 1999. With over 100 solutions, we support your in-house or outsourced projects with high quality products or services, including FDA-, EMA, PMDA-ready reports. Please visit our booth #205 and www.solvo.com!
SUVEN LIFE SCIENCES, LTD.
Suven Discovery has 15 years experience in discovery and development of several small molecules to clinic in CNS. Suven offers Medicinal-Chemistry, Analytical-Chemistry, Impurities-Metabolite Synthesis; ADME assays (Metabolic stability, Reaction phenotyping, Met ID, DDI- Inhibition & induction assays, Transporter assays, rodent and non-rodent PK and CNS penetration), Microdialysis; Receptor-Occupancy; In-vivo
Pharmacology; Toxicology and Bioanalysis.
THERMO FISHER SCIENTIFIC
The GibcoTM brand by Thermo Fisher Scientific provides cellbased products to accelerate the development of effective drugs. Our comprehensive portfolio of primary hepatocytes, media, and supplements to provide the stable foundation you need to confidently screen compounds for potential effects on liver function; our team of hepatic scientists will help you integrate these powerful tools.
UNIVERSITY OF WASHINGTON, DRUG INTERACTION DATABASE PROGRAM
The Metabolism & Transport Drug Interaction Program (www.druginteractioninfo.org) maintains web-based research applications (DIDB, e-PKGene) for pharmaceutical scientists and clinicians working in drug metabolism, drug transport, and drug-drug interactions. The platform contains preclinical and clinical drug interaction, organ impairment, and pharmacogenetic studies from the Literature and from recent
Waters Corporation creates business advantages for laboratory-dependent organizations by delivering scientific innovation to enable customers to make significant advancements. Waters helps customers make profound discoveries, optimize laboratory operations, deliver product performance, and ensure regulatory compliance with a connected portfolio of separations and analytical science, laboratory informatics, mass spectrometry, as well as thermal analysis.
WuXi AppTec Laboratory Testing Division (LTD) provides a comprehensive and integrated testing platform for drug development. LTD provides services and solutions in analytical chemistry, in vivo pharmacology, full-scale in vitro ADME and in vivo PK, bioanalysis, toxicology, clinical testing and customized antibody and reagent preparation in both China and the U.S.