Meeting Chair and Co-Chair Information
Jashvant Unadkat, Ph.D.
21st North American ISSX Meeting Chair
Jashvant (Jash) Unadkat, Ph.D. is the Gibaldi Endowed Professor in the School of Pharmacy at the University of Washington, Seattle.
He received his Bachelors degree in Pharmacy (B.Pharm.) from the University of London (1977), his Ph.D. from the University of Manchester (1982; advisor Prof. Malcolm Rowland) and his postdoctoral training at the University of California at San Francisco (1982-85; advisor Dr. Lewis Sheiner).
Dr. Unadkat’s research interests are focused on elucidating the mechanisms of transport and metabolism of HIV and related drugs. In particular his laboratory has been interested in metabolism and transport of drugs during pregnancy, and transport of drugs across the placental, hepatic, intestinal and blood-brain barrier. Dr. Unadkat has published more than 170 peer-reviewed research papers. He is a fellow of AAAS, AAPS, JSSX, and the founding co-chair (1999-2001) of the focus group of AAPS on Drug Transport and Uptake.
Dr. Unadkat received the AAPS Research Achievement Award in 2012. Dr. Unadkat created and leads the UW Research Affiliates Program on Transporters (UWRAPT), a cooperative effort between the UW School of Pharmacy and pharmaceutical companies. He also leads UWPKDAP, a NIDA funded Program Project grant (P01) on drug disposition during pregnancy. Dr. Unadkat has been an Associate Editor for the Journal of Pharmaceutical Sciences, an Editor of AAPS Journal, and a member of the NIH Pharmacology study section (2000-3). Dr. Unadkat is currently on the editorial board of J. Pharm. Sci. and the AAPS Journal. Dr. Unadkat has organized or co-organized numerous national and international conferences on the role of transporters and pregnancy in disposition of drugs.
Allan Rettie, Ph.D.
21st North American ISSX Meeting Co-Chair
Allan Rettie, Ph.D. is a professor in the Department of Medicinal Chemistry in the School of Pharmacy at the University of Washington, Seattle.
Dr. Rettie obtained a Ph.D. in Pharmaceutical Sciences in 1983 from the University of Newcastle-upon-Tyne, England, before moving to Seattle to post-doc with Drs. Mont Juchau and Dr. Bill Trager at the UW in the areas of extra-hepatic drug metabolism and mechanisms of drug-drug interactions. He joined the faculty of the UW School of Pharmacy in 1987 and was Department Chair from 2000-2014.
Dr. Rettie’s research interests have focused mainly on the human P450 enzymes and attempts to understand mechanisms of catalysis, substrate specificity, pharmacogenetic variability and adverse drug reactions related to these monooxygenases. He has published over 170 peer-reviewed papers and held research grants from the National Institutes of Health (NIH) in these topic areas for the last 25 years.
Dr. Rettie has served on the editorial boards of Drug Metabolism and Disposition, Drug Metabolism Reviews, Journal of Pharmacology and Therapeutics, Current Drug Metabolism, Chemico-Biological Interactions and Chemical Research in Toxicology, as well as numerous NIH grant review panels. He is Past Chair of the Scientific Affairs Committee of ISSX and is Past Chair of the International Union of Basic and Applied Pharmacology’s Section of Drug Metabolism and Transport. In 2005, Dr. Rettie received the North American Scientific Achievement Award from ISSX for his work on elucidating metabolic and pharmacogenetic mechanisms of adverse reactions to the anticoagulant drug, warfarin. He holds several patents relating to the clinical utility of warfarin response gene pharmacogenomics.