Thursday, September 28

7:45 am - 8:45 am
Industry-Sponsored Symposia (ISS)

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9:00 am - 9:45 am
Plenary Lecture 4

Pharmacogenomics to Parmaco-omics: Precision Medicine and Drug Response
Richard Weinshilboum, Mayo Clinic

9:45 am - 10:00 am
Refreshment Break

10:00 am - 12:00 pm
Parallel Symposia 11 and 12

Symposium 11: New Insights into P450 Structure, Emerging Transporters, and Application to Drug Development  
Chairs: Eric Johnson, The Scripps Research Institute and Joanne Wang, University of Washington

Structural Differences Exhibited by Cytochrome P450s 3A5 and 3A4
Eric Johnson, The Scripps Research Institute

Utilizing Structures of 2D6 and BACE1 to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Michael A. Brodney, Pfizer Worldwide Research and Development

Renal MATE Function in the Context of Drug Development
Stephen Wright, University of Arizona

Novel Organic Cation Transporter PMAT: Structure, Function, and Role in Drug Transport at the Blood-CSF Barrier
Joanne Wang, University of Washington

    Symposium 12: Emergent Technologies for Evaluating Drug and Xenobiotic Disposition
    Chairs: Ed Kelly, University of Washington and Jinping Gan, Bristol-Myers Squibb

    Utility of Microphysiological System (MPS) Technologies in Drug and Xenobiotic Safety Assessments
    Ed Kelly, University of Washington

    What Can Single-Molecule Fluorescence Tell Us About the Disposition of Large- and Small-Molecule Drugs? 
    Abhi Nath, University of Washington

    The Utility of 3D Hepatocyte Spheroids in Addressing Modern Problems in Drug Metabolism
    Jinping Gan, Bristol-Myers Squibb

    Visualizing Drug Disposition with MALDI Imaging MS
    Steve Castellino, GlaxoSmithKline

    12:00 pm - 12:15 pm
    Meeting Closing Remarks

    Closing Remarks
    Meeting Chair, Jashvant Unadkat, University of Washington and Meeting Co-Chair, Allan Rettie, University of Washington