Tuesday, September 26

7:45 am - 8:45 am
Industry-Sponsored Symposia (ISS)
Presented by Lonza

Direct and Quantitative Evaluation of CYP450 Contribution (fm) to Drug Clearance Using the in vitro Mod-el Silensomes™
Ashwani Sharma

View the symposium content here.

9:00 am - 9:45 am
Plenary Lecture 2

Making Drugs Great Again: Eliminating Idiosyncratic Drug Reactions
Jack Uetrecht, University of Toronto

10:15 am - 12:15 pm
Parallel Symposia 5 and 6

Symposium 5: ADME/PK Considerations for Next Generation Therapeutics: ADCs, Antibodies, Oligonucleotides, and Liposomes
Chairs: Anshul Gupta, Amgen and Steve Alley, Seattle Genetics

Targeted Drug Delivery and ADME of Antibody-Drug Conjugates
Steve Alley, Seattle Genetics

Imaging and Kinetics of Nanoparticle Disposition in Tumors and Tissues.
Mauricio Leal, Pfizer, Inc.

Pharmacokinetics and Pharmacodynamics of Oligonucleotide Therapeutics:  Different, but Strangely Familiar
Art Levin

In vitro & in vivo ADME Considerations for Guiding Engineering of Next Generation of Protein Therapeutics
Josh Pearson, Amgen

Symposium 6: Transporters and Enzymes: Novel Insights into the Regulation of Drug Disposition and Response
Chairs: Young Jeong, University of Illinois, Chicago and Guofeng You, Rutgers University

Role of lncRNAs in the Regulation of Drug Metabolizing Enzymes
Xiao-bo Zhong, University of Connecticut

Understanding the Gut Microbiome-Liver Axis in Xenobiotic Biotransformation
Julia Yue Cui, University of Washington

Genetic Regulation of Efflux Drug Transporters
Lauren Aleksunes, Rutgers University

Post-Translational Regulation of Influx Drug Transporters
Guofeng You, Rutgers University

12:15 pm - 1:00 pm
Lunch and Visit with Exhibitors

1:00 pm - 2:00 pm
Poster Presentations and E-Poster Theater Session: Drug Metabolism or Drug Toxicity

2:00 pm - 4:00 pm
Parallel Symposia 7 and 8

Symposium 7: Molybdenum Coenzymes (e.g. AO and XO) – Basics and Application
Chair: R. Scott Obach, Pfizer

Biochemical Aspects of Aldehyde and Xanthine Oxidase
Jeff Jones, Washington State University

Crystal Structure of Aldehyde Oxidase
Maria Joao Romao, Universidade Nova de Lisboa

Genetics, Regulation, and Endogenous Role for Aldehyde Oxidase
Enrico Garattini, Mario Negri Research Institute

Aldehyde Oxidase in Drug Design and Drug Discovery
R. Scott Obach, Pfizer

    Symposium 8: Interplay of Transporters and Mitochondrial/Lysosomal Drug Sequestration–Implications in Toxicity, Efficacy and Drug-Drug Interactions
    Chairs: Wei Yue, University of Oklahoma Health Sciences Center and Yingying Guo, Eli Lilly and Company

    Utility of Humanized Liver Mouse Model in Evaluation of Mitochondrial Transporters-Associated Hepatotoxicity
    Yingying Guo, Eli Lilly and Company

    Targeting the Lysosome with Novel Drugs to Overcome P-glycoprotein Mediated Resistance in Cancer
    Des R. Richardson, University of Sydney

    The Contribution of Lysosomal Sequestration to Intracellular Drug Accumulation and its Assessment by in vitro and in silico Methods
    Ayse Ufuk, University of Manchester

    Impaired OATP1B1-mediated Transport Following Treatment with Lysosomotropic Drug Chloroquine: Implications in OATP-mediated Drug-Drug Interactions
    Wei Yue, The University of Oklahoma Health Sciences Center

    4:00 pm - 4:30 pm
    Refreshment Break with Exhibitors

    4:30 pm - 6:00 pm
    Podium Presentations of Pre-doctoral/Graduate Poster Awards Finalists

    6:00 pm - 8:00 pm
    The New Investigators Forum: Career and Leadership Development

    Graduate students, postdoctoral fellows, and investigators in the early stages of their careers are invited to attend this free and informative session. The forum will provide insight into career opportunities in multiple segments of the pharmaceutical sciences (academia, "big pharma," biotech, and government), with an emphasis on both making oneself more "marketable" to potential employers and acquiring critical leadership skills for a successful career. Be sure to add this free event to your meeting registration.