Wednesday, September 27

7:45 am - 8:45 am
Industry-Sponsored Symposia (ISS)

Apply to sponsor an ISS.

9:00 am - 9:45 am
Plenary Lecture 3

Cancer Immunotherapy: Checkpoint Inhibitors, Adoptive Cell Therapy, and Beyond
Samuel C. Blackman, Silverback Therapeutics, Inc.

10:15 am - 12:00 pm
Presentation of the ISSX Awards

Postdoctoral and Pre-doctoral/Graduate Poster Awards

North American Scientific Achievement Award, Named in Honor of Ronald W. Estabrook

North American New Investigator Award, Named in Honor of James R. Gillette

12:00 pm - 1:00 pm
Lunch and Visit with Exhibitors

1:00 pm - 2:00 pm
Poster Presentations and E-Poster Theater Session: Immunotherapy/
CAR-T Therapy or Biological Therapeutics

2:00 pm - 4:00 pm
Parallel Symposia 9 and 10

Symposium 9: Mitochondrial Metabolism, Transport, and Toxicity
Chairs: Allan Rettie, University of Washington and Yvonne Will, Pfizer

Introduction to Basic Mitochondrial Biology as it Relates to Drug Induced Toxicity
James Dykens, EyeCyte Therapeutics

P450 Metabolism and Effects on Drug Accumulation/Toxicity: Examples of Compounds Causing Liver Injury
Narayan Avadhani, University of Pennsylvania

Mitochondrial Toxicity: In vitro Testing Paradigm and Potential Biomarker Development
Yvonne Will, Pfizer

    Symposium 10: Hydrolases: Enzymology and Role in Drug Development
    Chairs: Griff Humphreys, Bristol-Myers Squibb and Andrew Parkinson, XPD Consulting

    Evaluating in vivo Esterase-mediated Drug Metabolism: Should Be Easy, But Why Do We Fail? 
    Phil Potter, St. Jude Children's Research Hospital

    Chemical Biology Approaches to Profile Esterase Function
    Brent Martin, University of Michigan

    Genetic Polymorphisms of Carboxylesterases and their Clinical Implications
    Haojie Zhu, University of Michigan

    Functional Significance of Orphan Drug-metabolizing Esterases in Pharmacokinetics and Toxicities
    Tatsuki Fukami, Kanazawa University

    4:00 pm - 4:30 pm
    Refreshment Break with Exhibitors

    4:30 pm - 6:00 pm
    Abstract Session: Oral Presentations of Selected Abstracts

    This session will feature various topics with authors presenting slides from the podium. 

    6:30 pm - 10:00 pm
    Meeting Reception: Rooftop @ the ProvidenceG

    Enjoy a reception with New England flare when you join ISSX for a view of city skylines and stars at the Rooftop @ the ProvidenceG. Providence’s only rooftop lounge and restaurant features a fully enclosed glass rooftop, fire pits, and private lounges. With its perch seven stories up in the center of downtown, the views are awe inspiring.

    Tickets for this event are sold separately and may be purchased with your meeting registration.